Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 364537
Title Inactivation of the BSE agent by the heat and pressure process for manufacturing gelatine
Author(s) Grobben, A.H.; Steele, P.J.; Somerville, R.A.; Taylor, D.; Schreuder, B.E.C.
Source Veterinary Record 157 (2005)10. - ISSN 0042-4900 - p. 277 - 281.
Department(s) Central Institute for Animal Disease Control
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) bovine-spongiform-encephalopathy - creutzfeldt-jakob-disease - scrapie agent - rendering procedures - theoretical implications - person transmission - strains - mice - resistance - virus
Abstract Dietary exposure to the bovine spongiform encephalopathy (BSE) agent is the probable cause of variant Creutzfeldt-Jakob disease in people. The industrial manufacturing process for the production of gelatine and colloidal protein by the heat and pressure process was downscaled accurately and its capacity to remove or inactivate BSE infectivity was investigated. Gelatine was made from bones experimentally contaminated with mouse brain infected with the 301V strain of mouse-passaged BSE agent in which the infective titre was 108·7 ID50/g. No infectivity was detected in the extracted protein (100·45 ID50/g), and the calculated clearance factor was 106·5 ID50 or more.
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