Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 366595
Title The Secretory Function of Adipocytes in the Physiology of White Adipose Tissue
Author(s) Wang, P.; Mariman, E.; Renes, J.; Keijer, J.
Source Journal of Cellular Physiology 216 (2008)1. - ISSN 0021-9541 - p. 3 - 13.
DOI https://doi.org/10.1002/jcp.21386
Department(s) RIKILT - Business Unit Safety & Health
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) colony-enhancing factor - type-2 diabetes-mellitus - migration inhibitory factor - mature 3t3-l1 adipocytes - necrosis-factor-alpha - insulin-resistance - gene-expression - mitochondrial biogenesis - metabolic syndrome - in-vivo
Abstract White adipose tissue, previously regarded as a passive lipid storage site, is now viewed as a dynamic tissue. It has the capacity to actively communicate by sending and receiving different types of signals. An overview of these signals, the external modulators that affect adipose tissue and the secreted signaling molecules, the adipokines, is presented. The secretory function is highlighted in relation to energy metabolism, inflammation and the extracellular matrix and placed in the context of adipose tissue biology. We observe that the endocrine function of adipocytes receives much attention, while its paracrine and autocrine functions are underestimated. Also, we provide examples that species specificity should not be neglected. We conclude that adipose tissue primarily is an energy storage organ, well supported by its secretory function
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