Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 367267
Title Beyond induced mutants: using worms to study natural variation in genetic pathways
Author(s) Kammenga, J.E.; Philips, P.C.; Bono, M. de; Doroszuk, A.
Source Trends in Genetics 24 (2008)4. - ISSN 0168-9525 - p. 178 - 185.
DOI https://doi.org/10.1016/j.tig.2008.01.001
Department(s) Laboratory of Nematology
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) quantitative trait loci - life-history traits - genotype-environment interactions - single-nucleotide polymorphisms - nematode caenorhabditis-elegans - c-elegans - linkage disequilibrium - genus caenorhabditis - wild populations - expression
Abstract Induced mutants in the nematode Caenorhabditis elegans are used to study genetic pathways of processes ranging from aging to behavior. The effects of such mutations are usually analyzed in a single wildtype background: N2. However, studies in other species demonstrate that the phenotype(s) of induced mutations can vary widely depending on the genetic background. Moreover, induced mutations in one genetic background do not reveal the allelic effects that segregate in natural populations and contribute to phenotypic variation. Because other wildtype Caenorhabditis spp., including C. elegans, are now available, we review how current mapping resources and methodologies within and between species support the use of Caenorhabditis spp. for studying genetic variation, with a focus on pathways associated with human disease.
Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.