Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 367525
Title Observer design and tuning for biomass growth and kLa using online and offline measurements
Author(s) Soons, Z.I.T.A.; Shi, J.; Stigter, J.D.; Pol, L.A. van der; Straten, G. van; Boxtel, A.J.B. van
Source Journal of Process Control 18 (2008)7-8. - ISSN 0959-1524 - p. 621 - 631.
DOI https://doi.org/10.1016/j.jprocont.2007.12.008
Department(s) Systems and Control Group
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) extended kalman filter - parameter-estimation - bordetella-pertussis - batch fermentation - state estimation - off-line - bioreactor - estimator - systems - reactor
Abstract Measurement of the key process variables is essential during biopharmaceutical production. These measurements are often not available online. This work combines frequent online measurements (oxygen uptake rate) with infrequent offline measurements (biomass) to estimate the specific growth rate, biomass, and the oxygen transfer coefficient (kLa) online. The system consists of an extended Kalman filter and parameter adaptation for the time-varying kLa. Tuning is based on minimization of the error between the simulation and the estimation. Although the process itself is not stable, stability of the observer is evaluated heuristically by application of the Routh criterion. Performance and convergence of the observer are shown in both simulations and experiments in continuous and fed-batch cultivations of Bordetella pertussis.
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