Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 367724
Title a+- Thalassemia Protects against Anemia Associated with Asymptomatic Malaria: Evidence from Community-Based Surveys in Tanzania and Kenya
Author(s) Veenemans, J.; Andang'o, P.E.A.; Mbugi, E.V.; Kraaijenhagen, R.; Mwaniki, D.; Mockenhaupt, F.P.; Roewer, S.; Olomi, R.M.; Shao, J.F.; Meer, J.W.M. van der; Savelkoul, H.F.J.; Verhoef, J.C.M.
Source The Journal of Infectious Diseases 198 (2008). - ISSN 0022-1899 - p. 401 - 408.
DOI https://doi.org/10.1086/589884
Department(s) Cell Biology and Immunology
Chair Nutrition and Health over the Lifecourse
VLAG
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) plasmodium-falciparum infection - sickle-cell trait - alpha-thalassemia - african children - lactate-dehydrogenase - northern ghana - disease - transmission - childhood - coast
Abstract Background. In hospital-based studies, ¿+-thalassemia has been found to protect against severe, life-threatening falciparum malaria. ¿+-Thalassemia does not seem to prevent infection or high parasite densities but rather limits progression to severe disease¿in particular, severe malarial anemia. We assessed to what extent ¿+-thalassemia influences the association between mild, asymptomatic Plasmodium falciparum infection and hemoglobin concentration. Methods. The study was based on 2 community-based surveys conducted among afebrile children (0.5¿8 years old; ) in Kenya and Tanzania. Results. Among children without inflammation (whole-blood C-reactive protein concentration 10 mg/L), P. falciparum infection was associated with only small reductions in hemoglobin concentration, and effects were similar across ¿-globin genotypes. By contrast, the reduction in hemoglobin concentration associated with P. falciparum infection accompanied by inflammation was larger and strongly depended on genotype (normal, ¿21.8 g/L; heterozygous, ¿16.7 g/L; and homozygous, ¿4.6 g/L). Relative to children with a normal genotype, this difference in effect was 5.1 g/L (95% confidence interval [CI], ¿1.0 to 11.1 g/L) for heterozygotes and 17.2 g/L (95% CI, 8.3 to 26.2 g/L) for homozygotes (estimates are adjusted for study site, age, height-for-age z score, and iron deficiency). Conclusions. ¿+-Thalassemia limits the decline in hemoglobin concentration that is associated with afebrile infections, particularly those that are accompanied by inflammation.
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