Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 368150
Title Mass spectrometric analysis of the marine lipophilic biotoxins pectenotoxin-2 and okadaic acid by four different types of mass spectrometers
Author(s) Gerssen, A.; Mulder, P.P.J.; Rhijn, J.A. van; Boer, J. de
Source Journal of Mass Spectrometry 43 (2008)8. - ISSN 1076-5174 - p. 1140 - 1147.
DOI https://doi.org/10.1002/jms.1407
Department(s) RIKILT - Analyse & Ontwikkeling
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) shellfish-poisoning toxins - performance liquid-chromatography - dinophysistoxin-1 - identification - yessotoxin - analogs - mice
Abstract The performances of four different mass spectrometers [triple-quadrupole (TQ), time-of-flight (ToF), quadrupole ToF (Q-ToF) and ion trap (IT)] for the detection of the marine lipophilic toxins pectenotoxin-2 (PTX2) and okadaic acid (OA) were investigated. The spectral data obtained with the different mass spectrometric analyzers were used to propose fragmentation schemes for PTX2 in the positive electrospray mode and for OA in the negative electrospray mode. TQ data were used to obtain product ions, while ToF and Q-ToF-MS produced accurate mass data of the precursor ion and product ions, respectively. IT data provided a better understanding of the fragmentation pathways using MSn experiments. With respect to analytical performance, all four mass analyzers showed a good linearity (R2 > 0.97) and repeatability (CV <20%). Detection limits (LoDs) (S/N = 3) were the lowest on triple-quad MS: 12.2 and 2.9 pg on-column for PTX2 and OA, respectively
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