Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 369312
Title Deacylation of antibiotic A40926 by immobilized Actinoplanes teichomyceticus cells in an internal-loop air-lift bioreactor
Author(s) Jovetic, S.; Bresser, L. de; Tramper, J.; Marinelli, F.
Source Enzyme and Microbial Technology 32 (2003)5. - ISSN 0141-0229 - p. 546 - 552.
Department(s) Bioprocess Engineering
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) carrageenan - beads
Abstract A40926 is a natural glycopeptide antibiotic. It is a precursor of dalbavancin, a semi-synthetic second-generation glycopeptide in clinical development for the treatment of ß-lactam-resistant Staphyloccous aureus and Staphylococcus epidermidis infections. Deacylation of A40926, producing an intermediate useful for the synthesis of novel derivatives, can be carried out by the action of Actinoplanes teichomyceticus cells. Kinetics parameters for this particular deacylation reaction were obtained by fitting the experimental data to a Michaelis¿Menten kinetic model. The feasibility of A40926 deacylation by immobilized A. teichomyceticus cells in an air-lift bioreactor was examined. A single continuously operated air-lift reactor (ALR) was evaluated by a model describing diffusion and reaction in the biocatalyst beads. Model estimates were in a good agreement with experimental results. The system was operated continuously for 21 days with overall conversion above 60%.
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