Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 369319
Title Enantiomer separation in a cascaded micellar-enhanced ultrafiltration system
Author(s) Overdevest, P.E.M.; Hoenders, M.H.J.; Riet, K. van 't; Padt, A. van der; Keurentjes, J.T.F.
Source AIChE Journal 48 (2002)9. - ISSN 0001-1541 - p. 1917 - 1926.
Department(s) Sub-department of Food and Bioprocess Engineering
Food Process Engineering
Publication type Refereed Article in a scientific journal
Publication year 2002
Keyword(s) nonlinear chromatographic separations - moving-bed units - enantioselective complexation - optimal operation - racemic-mixture - robust design - (d/l)-phenylalanine - kinetics
Abstract The increasing demand for optically pure compounds (enantiomers) stimulates the development of new enantiomer separation processes on an industrial scale. The separation of enantiomers by ultrafiltration of enantioselective micelles was studied in a cascaded system. The feasibility of this separation concept was proven by a cascade of five lab-scale units and a bench-scale system using an industrial membrane module. Model calculations show that the separation is not improved greatly at enantioselectivities (ratio of affinity constants) above 10 and the affinity of the enantioselective micelles for the substrate (enantiomers) plays a crucial role in the performance of the separation process. Modeling the separation as a function of the dimensionless affinity number (affinity constant · enantiomer feed concentration) shows that there is an operation window in which the separation satisfies its criterion of high yield and high enantiomeric excess. For countercurrent affinity systems, this implies that any research effort should focus on developing (microheterogeneous) media characterized by weak interactions with the substrate to allow for operation at high feed concentrations, not on high affinity systems
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