Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 369847
Title Adipokines in the prevention of type 2 diabetes: The effect of a long-term lifestyle intervention
Author(s) Blaak, E.E.; Roumen, C.; Corpeleijn, E.; Saris, W.H.M.; Feskens, E.J.M.
Source Diabetologia 51 (2008)Suppl. 1. - ISSN 0012-186X - p. S148 - S148.
Department(s) Chair Nutrition and Disease
VLAG
Publication type Abstract in scientific journal or proceedings
Publication year 2008
Abstract Background and aims: We investigated the effect of a 4.2 year lifestyle intervention according to general recommendations on circulating adipokine concentrations and inflammation markers in subjects at risk for diabetes as well as the potential of leptin, adiponectin, resistin, plasminogen activator inhibitor 1 (PAI-1) and Complement factor 3 (C3) as biomarkers for lifestyleinduced improvements in glucose metabolism and insulin resistance. Materials and methods: In the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht, 147 men and women with impaired glucose olerance (IGT) were randomized to either a combined diet-and-exercise intervention (INT) or a control program (CON). At baseline and at the end of the study (after 4 or 6 years) adipokines and inflammation were measured in addition to performance of an oral glucose tolerance test, an exercise test, and anthropometric measurements. At the end of the study, complete data of 92 subjects (49 INT,43 CON) were obtained. Results: Lifestyle intervention increased carbohydrate intake, improved maximal aerobic capacity (VO2 max) and reduced diabetes incidence by 31 % (pall
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