Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 370335
Title ALC ((a)under-bardjacent to (L)under-barMX1 in (c)under-barhick) is a novel dorsal limb mesenchyme marker
Author(s) Holmes, G.; Crooijmans, R.P.M.A.; Groenen, M.A.M.; Niswander, L.
Source Gene Expression Patterns 3 (2003)6. - ISSN 1567-133X - p. 735 - 741.
Department(s) Animal Breeding and Genetics
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) vertebrate limb - transcription factor - chick - expression - pattern - lmx1 - wnt7a
Abstract During dorsal¿ventral (DV) patterning of the vertebrate limb, WNT7A is expressed in dorsal limb ectoderm and activates the expression of LMX1 (in chick; Lmx1b in mouse) in dorsal limb mesenchyme, resulting in the appropriate development of dorsal cell fates. These two genes are the only known factors involved in directing dorsal patterning and the molecular events that link these two factors or that occur downstream of LMX1/1b are unknown. We have isolated a novel chick transcript, ALC (adjacent to LMX1 in chick). ALC is located 5.3 kb from the 5¿ end of LMX1 and is transcribed in the opposite direction. It is expressed in a sub-set of tissues expressing LMX1, most notably in the dorsal mesenchyme of the limb, and thus is the second gene discovered with such a distribution in the limb. Misexpression studies with viral constructs show that ALC is downstream of WNT7A but not of LMX1. ALC shows no homology to known genes and its function remains to be determined. However, similarly placed transcripts occur in the human and mouse genomes, and we demonstrate that a mouse transcript is also expressed in dorsal limb mesenchyme
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