Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 370495
Title Combined age and segregated kinetic model for industrial-scale penicillin fed-batch cultivation
Author(s) Wang, Z.F.; Lauwerijssen, M.J.C.; Yuan, J.Q.
Source Biotechnology and Bioprocess Engineering 10 (2005)2. - ISSN 1226-8372 - p. 142 - 148.
Department(s) Sub-department of Food and Bioprocess Engineering
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) cell cycling model - bakers-yeast - chrysogenum
Abstract This paper proposes a cell age model forPenicillium chrysogenum fed-batch cultivation to supply a qualitative insight into morphology-associated dynamics. The average ages of the segregated cell populations, such as growing cells, non-growing cells and intact productive cells, were estimated by this model. A combined model was obtained by incorporating the average ages of the cell sub-populations into a known but modified segregated kinetic model from literature. For simulations, no additional effort was needed for parameter identification since the cell age model has no internal parameters. Validation of the combined model was performed by 20 charges of industrial-scale penicillin cultivation. Meanwhile, only two charge-dependent parameters were required in the combined model among approximately 20 parameters in total. The model is thus easily transformed into an adaptive model for a further application in on-line state variables prediction and optimal scheduling
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