Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 370500
Title The European LABDEL project and its relevance to the prevention and treatment of allergies
Author(s) Daniel, C.; Repa, A.; Mercenier, A.M.E.; Wiedermann, U.; Wells, J.
Source Allergy 62 (2007)11. - ISSN 0105-4538 - p. 1237 - 1242.
Department(s) Host Microbe Interactomics
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) lactic-acid bacteria - birch pollen allergen - bovine beta-lactoglobulin - t-regulatory cells - immune-responses - immunoglobulin-e - murine model - in-vivo - disease - immunotherapy
Abstract In March 2001, the European Commission funded a 3-year project (contract no. QLK3-CT-2000-00340) under the fifth Framework Programme to develop and test prototype products based on the oral delivery of vaccine and therapeutic agents using harmless lactic acid bacteria (LAB). The project, best known under its acronym LABDEL (for LAB delivery) also included research on LAB fermentation and technological innovations aimed at enhancing the efficiency of LAB delivery systems (1). One of the key scientific objectives was to investigate the possibility to prevent or treat a type I allergic disease using mucosal administration of LAB expressing the pollen allergen Bet v 1. The aim of this paper was to describe the background of the project with reference to a limited selection of articles and recent reviews as well as the results and major conclusions arising from this part of the project.
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