Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 371521
Title Response regulator important in pathogenesis of Streptococcus suis serotype 2
Author(s) Greeff, A. de; Buijs, H.; Alphen, L. van; Smith, H.E.
Source Microbial Pathogenesis 33 (2002)4. - ISSN 0882-4010 - p. 185 - 192.
DOI https://doi.org/10.1006/mpat.2002.0526
Department(s) ID - Infectieziekten
Publication type Refereed Article in a scientific journal
Publication year 2002
Keyword(s) virulence genes - infection - pigs - identification - transformation - pneumoniae - selection - protein - strains
Abstract In this study, we describe the first response regulator of Streptococcus suis serotype 2, designated RevS. RevS was cloned and the sequence was determined. No histidine kinase was found in the vicinity ofrevS , therefore RevS was considered to be an orphan response regulator. An isogenic knock-out mutant of RevS was shown to be attenuated in colonising the S. suis specific organs in a competitive assay in four piglets, indicating thatrevS plays a role in the pathogenesis of S. suis infections. We analysed the protein expression profiles of various fractions of the wild-type strain 10 and the mutant strain 10¿RevS. The expression of known virulence factors ofS. suis by wild-type and the mutant strain, was not different. However, one protein in the protoplast fraction, with unknown identity was shown to be repressed by revS in the exponential growth phase of the mutant
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