Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 371569
Title A randomised controlled trial into the effects of food and ADHD
Author(s) Pelsser, L.; Frankena, K.; Toorman, J.; Savelkoul, H.F.J.; Rodrigues Pereira, R.; Buitelaar, J.
Source European Child & Adolescent Psychiatry 18 (2009)1. - ISSN 1018-8827 - p. 12 - 19.
DOI https://doi.org/10.1007/s00787-008-0695-7
Department(s) Quantitative Veterinary Epidemiology
Cell Biology and Immunology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2009
Keyword(s) attention-deficit/hyperactivity disorder - cognitive-behavior therapy - chronic-fatigue-syndrome - oligoantigenic diet - hyperactive boys - double-blind - children - additives - adolescents - multicenter
Abstract The aim of this study is to assess the efficacy of a restricted elimination diet in reducing symptoms in an unselected group of children with Attention deficit/hyperactivity disorder (ADHD). Dietary studies have already shown evidence of efficacy in selected subgroups. Twenty-seven children (mean age 6.2) who all met the DSM-IV criteria for ADHD, were assigned randomly to either an intervention group (15/27) or a waiting-list control group (12/27). Primary endpoint was the clinical response, i.e. a decrease in the symptom scores by 50% or more, at week 9 based on parent and teacher ratings on the abbreviated ten-item Conners Scale and the ADHD-DSM-IV Rating Scale. The intention-to-treat analysis showed that the number of clinical responders in the intervention group was significantly larger than that in the control group [parent ratings 11/15 (73%) versus 0/12 (0%); teacher ratings, 7/10 (70%) versus 0/7 (0%)]. The Number of ADHD criteria on the ADHD Rating Scale showed an effect size of 2.1 (cohen¿s d) and a scale reduction of 69.4%. Comorbid symptoms of oppositional defiant disorder also showed a significantly greater decrease in the intervention group than it did in the control group (cohens¿s d 1.1, scale reduction 45.3%). A strictly supervised elimination diet may be a valuable instrument in testing young children with ADHD on whether dietary factors may contribute to the manifestation of the disorder and may have a beneficial effect on the children¿s behaviour.
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