Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 371642
Title Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation
Author(s) Lee, Y.Y.; Stolaki, M.; Berkel, W.J.H. van; Aarts, J.M.M.J.G.; Rietjens, I.M.C.M.
Source Food and Chemical Toxicology 46 (2008)6. - ISSN 0278-6915 - p. 2128 - 2134.
Department(s) Biochemistry
Sub-department of Toxicology
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) dietary polyphenols - in-vitro - metabolic-fate - flavonoids - expression - absorption - glycosides - humans - cells - model
Abstract Quercetin is a flavonoid reported to have health-promoting properties. Due to its extensive metabolism to glucuronides in vivo, questions were raised if studies conducted with quercetin aglycone, stating its health-promoting activity, are of actual relevance. Here we show that glucuronides of quercetin, and its methylated forms isorhamnetin and tamarixetin, can induce EpRE-mediated gene expression up to 5-fold. Furthermore, evidence is presented that EpRE-mediated gene induction by these glucuronides involves their deglucuronidation. This indicates that although quercetin-derived glucuronides are the major metabolites present in the systemic circulation, deglucuronidated derivatives are the active compounds responsible for their beneficial EpRE-mediated gene expression effects.
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