Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 371972
Title Differential transcription of alpha-2-macroglobulin in carp (Cyprinus carpio) infected with parasites
Author(s) Onara, D.F.; Forlenza, M.; Gonzalez, S.F.; Rakus, K.L.; Pilarczyk, A.; Irnazarow, I.; Wiegertjes, G.F.
Source Developmental and Comparative Immunology 32 (2008)4. - ISSN 0145-305X - p. 339 - 347.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) ciliate ichthyophthirius-multifiliis - polymerase chain-reaction - growth-factor-beta - rainbow-trout - oncorhynchus-mykiss - pathogenic hemoflagellate - cryptobia-salmositica - trypanoplasma-borreli - alpha-macroglobulins - cysteine proteases
Abstract Alpha-2-macroglobulin (a2M) is a non-specific protease inhibitor involved in host defense mechanisms, inhibiting both endogenous and exogenous proteases. It is unique among the plasma anti-proteases with respect to the diversity of proteases that it can inactivate. Carp a2M consists of an alpha and beta chain of which the first includes the bioactive regions. Previously, three a2M alpha chain sequences were reported for East-Asian common carp. We studied a2M alpha chain variability in European common carp and report the cloning of a fourth a2M alpha chain with distinct sequence diversity in the bait region. The role of a2M in the immune response to parasites was studied in the liver of carp infected with Trypanoplasma borreli or with Ichthyophthirius multifiliis. Quantitative gene transcription analysis showed a differential regulation of the four isoforms, most clearly seen in infections with I. multifiliis. A2M3 was the only a2M isoform with a highly upregulated transcription during infection, suggesting that this particular isoform is of foremost biological importance.
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