Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 371973
Title Immune stimulation in fish and chicken through weak low frequency electromagnetic fields
Author(s) Cuppen, J.J.M.; Wiegertjes, G.F.; Lobee, H.W.J.; Savelkoul, H.F.J.; Elmusharaf, M.A.; Beynen, A.C.; Grooten, H.N.A.; Smink, W.
Source Environmentalist 27 (2007)4. - ISSN 0251-1088 - p. 577 - 583.
DOI https://doi.org/10.1007/s10669-007-9055-2
Department(s) Cell Biology and Immunology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2007
Abstract A hypothesis is proposed how Low Frequency Electromagnetic Field (LF EMF) exposure can stimulate an immune response, based on recent insights in immunology. We hypothesize that the Immunent EMF treatment induces mild stress to cells, which then produce cytokines that function as alarms or so called danger signals for the immune system. In this way EMF treatment takes the place of multiplying pathogens, and the damage these cause, in the triggering of an immune response. In a first series of experiments in¿vitro common carp head kidney-derived phagocytes were used to determine ROS production as a measure for immune activation. Exposure to LF EMF signals (200¿5,000 Hz) at 5 ¿T or 1.5 mT led to 42 or 33% increase in immune activity, respectively, compared to negative control values. EMF could also additionally stimulate chemically pre-stimulated samples up to 18% (5 ¿T) or 22% (1.5 mT). Significance of increase in ROS production in the total series was: p <0.0001. In a second series of experiments in¿vitro commercial goldfish were used. Groups of fish were housed under equal conditions in at least four control tanks and 8¿16 EMF-exposed tanks. Exposure was done with a predominantly vertical field at field strengths (rms) between 0.15 and 50 ¿T. Without treatment mortality was about 50% after 18 days, while the treatment at 5 ¿T reduced it to 20% on average. At field strengths 0.15, 0.5, 1.5, 5, 15 and 50 ¿T an equally strong effect was found. Reducing the field strength to 0.05, 0.06, 0.01 and 0.003 ¿T showed a gradually decreasing effect, which only at 0.003 ¿T is no longer statistically significant. Finally, in¿vitro experiments were done with 560 commercial broiler chickens exposed to infection pressure from coccidiosis. EMF exposure at 6.5 ¿T reduced intestinal lesions by 40% and improved feed conversion by 8%.
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