Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 372356
Title Persistence and coexistence of engineered baculoviruses
Author(s) Bonsall, M.B.; O'Reilly, D.R.; Cory, J.S.; Hails, R.S.
Source Theoretical Population Biology 67 (2005)4. - ISSN 0040-5809 - p. 217 - 230.
DOI https://doi.org/10.1016/j.tpb.2005.01.003
Department(s) Laboratory of Virology
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) insect-pathogen interactions - nuclear polyhedrosis-virus - udp-glucosyl transferase - recombinant baculovirus - trichoplusia-ni - egt gene - population-dynamics - spodoptera-exigua - gypsy-moth - host
Abstract Baculoviruses, and in particular, the nucleopolyhedroviruses infect a wide range of arthropod hosts and have the potential to be used as biopesticides. However, one of the major drawbacks with these pathogens as biocontrol agents is that they have a slow response time. Alterations to the speed of kill and pathogen life history characteristics can influence the competitive outcome and persistence between wildtype and modified strains. Here, we explore, theoretically, how life-history modifications of pathogens can affect the epidemiology and ecology of strain coexistence. In particular, we show how under simple mass action disease transmission, life-history difference between strains are insufficient to allow coexistence. Additional heterogeneities in transmission are shown to be necessary to facilitate coexistence of wildtype and modified pathogen strains. We also illustrate how the patterns of infectivity of wildtype and modified strains can also affect long-term coexistence, and argue that appropriate assessment of genetic modifications must be presented in terms of relevant ecological theory.
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