Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 372376
Title Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology
Author(s) Heijne, W.H.M.; Kienhuis, A.S.; Ommen, B. van; Stierum, R.; Groten, J.P.
Source Expert Review of Proteomics 2 (2005)5. - ISSN 1478-9450 - p. 767 - 780.
Department(s) RIKILT - Business unit Bioanalysis & Toxicology
Sub-department of Toxicology
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) gene-expression patterns - 2-dimensional gel-electrophoresis - laser desorption/ionization-time - magnetic-resonance spectroscopy - complementary-dna microarray - ionization mass-spectrometry - coded affinity tags - in-vitro - rat hepatocytes - induced hepatotoxic
Abstract Toxicogenomics can facilitate the identification and characterization of toxicity, as illustrated in this review. Toxicogenomics, the application of the functional genomics technologies (transcriptomics, proteomics and metabolomics) in toxicology enables the study of adverse effects of xenobiotic substances in relation to structure and activity of the genome. The advantages and limitations of the different technologies are evaluated, and the prospects for integration of the technologies into a systems biology or systems toxicology approach are discussed. Applications of toxicogenomics in various laboratories around the world show that the crucial steps and sequence of events at the molecular level can be studied to provide detailed insights into mechanisms of toxic action. Toxicogenomics allowed for more sensitive and earlier detection of adverse effects in (animal) toxicity studies. Furthermore, the effects of exposure to mixtures could be studied in more detail. This review argues that in the (near) future, human health risk assessment will truly benefit from toxicogenomics (systems toxicology).
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