Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 372475
Title Construction Of A Genetic Map For Detailed Milk Composition QTL Mapping In HF Cattle
Author(s) Koks, P.D.; Visker, M.H.P.W.; Schennink, A.; Arendonk, J.A.M. van; Poel, J.J. van der; Groenen, M.A.M.
Department(s) Animal Breeding and Genetics
Publication type Abstract in scientific journal or proceedings
Publication year 2008
Abstract A genetic map was constructed in order to map QTLs for a large amount of very detailed milk composition related phenotypes. Blood samples were collected from 5 large half-sib families of Dutch Holstein Friesian daughters from major breeding sires and from a number of smaller half-sib families. In order to maximise the putative information content SNPs were selected from previous genotyping experiments in the HF population and from dbSNP. Criteria for inclusion in our panel were that SNPs should a) cover chromosomes on both the genetic map and the physical map fairly even-spaced and equally dense, and b) be heterozygous in the majority of the sires of our population. Over 95% of the selected SNPs could be anchored to chromosomal scaffolds in the 3rd generation bovine genome assembly (BTAU3.1) using BLAT. We genotyped our families of in total nearly 900 heifers and sires in a whole genome scan with a panel of 1536 SNPs. Subsequently, genetic maps were constructed for all autosomes using CriMap. The resulting maps showed good coverage. Marker orders were largely in accordance with the physical map. Mean marker density of less than 5 cM and approximately 50% marker heterozygosity over all sires were as envisioned. This high quality genetic map is currently used within a QTL analysis of the milk composition traits
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