Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 387454
Title Whole genome scan to detect quantitative trait loci for bovine milk protein composition
Author(s) Schopen, G.C.B.; Koks, P.D.; Arendonk, J.A.M. van; Bovenhuis, H.; Visker, M.H.P.W.
Source Animal Genetics 40 (2009)4. - ISSN 0268-9146 - p. 524 - 537.
Department(s) Animal Breeding and Genetics
Publication type Refereed Article in a scientific journal
Publication year 2009
Keyword(s) cheese-making properties - beta-lactoglobulin gene - dairy-cattle - cows milk - osteopontin gene - variants - casein - polymorphism - parameters - map
Abstract The objective of this study was to perform a whole genome scan to detect quantitative trait loci (QTL) for milk protein composition in 849 Holstein–Friesian cows originating from seven sires. One morning milk sample was analysed for the major milk proteins using capillary zone electrophoresis. A genetic map was constructed with 1341 single nucleotide polymorphisms, covering 2829 centimorgans (cM) and 95% of the cattle genome. The chromosomal regions most significantly related to milk protein composition (Pgenome <0.05) were found on Bos taurus autosomes (BTA) 6, 11 and 14. The QTL on BTA6 was found at about 80 cM, and affected aS1-casein, aS2-casein, ß-casein and ¿-casein. The QTL on BTA11 was found at 124 cM, and affected ß-lactoglobulin, and the QTL on BTA14 was found at 0 cM, and affected protein percentage. The proportion of phenotypic variance explained by the QTL was 3.6% for ß-casein and 7.9% for ¿-casein on BTA6, 28.3% for ß-lactoglobulin on BTA11, and 8.6% for protein percentage on BTA14. The QTL affecting aS2-casein on BTA6 and 17 showed a significant interaction. We investigated the extent to which the detected QTL affecting milk protein composition could be explained by known polymorphisms in ß-casein, ¿-casein, ß-lactoglobulin and DGAT1 genes. Correction for these polymorphisms decreased the proportion of phenotypic variance explained by the QTL previously found on BTA6, 11 and 14. Thus, several significant QTL affecting milk protein composition were found, of which some QTL could partially be explained by polymorphisms in milk protein genes.
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