Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400032
Title Are antibiotic screening approaches sufficiently adequate? A proficiency test
Author(s) Berendsen, B.J.A.; Pikkemaat, M.G.; Stolker, A.A.M.
Source Analytica Chimica Acta 685 (2011)2. - ISSN 0003-2670 - p. 170 - 175.
DOI http://dx.doi.org/10.1016/j.aca.2010.11.029
Department(s) RIKILT - Analyse & Ontwikkeling
RIKILT - Business Unit Safety & Health
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) antimicrobial residues - mass-spectrometry - veterinary drugs - uplc-tof - muscle - milk - laboratories - validation - samples - kidney
Abstract A proficiency test including the screening analysis of antibiotics in beef using cryogenicly minced materials was organized by RIKILT in 2009. The test included blank beef samples and beef samples spiked with either flumequine or a combination of lincomycin and spectinomycin around the maximum residue limits [1]. The suitability of the materials was demonstrated with a homogeneity and a stability study. This study showed that cryogenically minced spiked muscle material is suited for proficiency tests aiming at the screening and the confirmatory analysis. Of the 26 participants, 23 carried out their in-house screening approach involving microbial, biochemical or instrumental methods, or a combination of these to cover the broad range of antibiotic groups. The false negative rate was 73% for microbial methods, 50% for biochemical and 22% for instrumental methods. These results indicate that substantial effort is needed to improve screening approaches and that more regular proficiency tests are needed to reveal the shortcomings in the currently applied screening methods.
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