Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 400099
Title Mucin-bacterial interactions in the human oral cavity and digestive tract
Author(s) Derrien, M.M.N.; Passel, M.W.J. van; Bovenkamp, J.H.B. van de; Schipper, R.G.; Vos, W.M. de
Source Gut Microbes 1 (2010)4. - ISSN 1949-0976 - p. 254 - 268.
DOI http://dx.doi.org/10.4161/gmic.1.4.12778
Department(s) Microbiological Laboratory
Food Chemistry Group
VLAG
WIMEK
Publication type Refereed Article in a scientific journal
Publication year 2010
Abstract Mucins are a family of heavily glycosylated proteins that are the major organic components of the mucus layer, the protective layer covering the epithelial cells in many human and animal organs, including the entire gastro-intestinal tract. Microbes that can associate with mucins benefit from this interaction since they can get available nutrients, experience physico-chemical protection and adhere, resulting an increased residence time. Mucin-degrading microorganisms, which often are found in consortia, have not been extensively characterized as mucins are high molecular weight glycoproteins that are hard to study because of their size, complexity, and heterogeneity. The purpose of this review is to discuss how advances in mucus and mucin research, and insight in the microbial ecology promoted our understanding of mucin degradation. Recent insight is presented in mucin structure and organization, the micro-organisms known to use mucin as growth substrate, with a specific attention on Akkermansia muciniphila, and the molecular basis of microbial mucin degradation owing to availability of genome sequences
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