Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400123
Title Targeted and untargeted profiling of biological fluids to screen for anabolic practices in cattle
Author(s) Pinel, G.; Weigel, S.; Antigac, P.; Mooney, M.H.; Elliott, C.; Nielen, M.W.F.; Bizec, B. le
Source TrAC : Trends in Analytical Chemistry 29 (2010)11. - ISSN 0165-9936 - p. 1269 - 1280.
Department(s) RIKILT - Analyse & Ontwikkeling
Laboratory for Organic Chemistry
RIKILT - R&C Groeibevorderaars
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) flight mass-spectrometry - human growth-hormone - gene-expression-biomarkers - veal calves - liquid-chromatography - human urine - doping control - factor-i - promoting purposes - steroids
Abstract This review deals with the potential of profiling approaches as valuable tools for combating the illegal use of growth promoters in cattle breeding. Detection of illegal practices classically relies on residue monitoring in a targeted approach and methods based on gas or liquid chromatography coupled to (tandem) mass spectrometry are considered state of the art. However, these strategies fail when faced with new xenobiotic growth-promoting agents or new ways of application, such as administration of low-dose cocktails. In this context, screening strategies allowing detection of the physiological response resulting from administration of anabolic compounds are promising approaches to detect misuse. Profiling biological matrices to reveal biological effects of a drug can be performed by targeting a particular class of compounds or in an untargeted way using global strategies, such as transcriptomics, proteomics or metabolomics. These emerging tactics are promising ways to highlight candidate biomarkers to tackle illegal practices.
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