Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400339
Title New approach to analyse spin probe and spin trap ESR
Author(s) Makarova, K.
Source University. Promotor(en): Herbert van Amerongen, co-promotor(en): Henk van As. - [S.l. : S.n. - ISBN 9789085858409 - 145
Department(s) Biophysics
EPS-2
Publication type Dissertation, internally prepared
Publication year 2011
Keyword(s) paramagnetische elektronenresonantiespectroscopie - chemische reacties - vrije radicalen - biofysica - electron paramagnetic resonance spectroscopy - chemical reactions - free radicals - biophysics
Categories Biophysics (General)
Abstract The goal of this thesis is to develop new comprehensive methods for the analysis of ESR spectra and interpretation of magnetic parameters. A new approach for the analysis of fast isotropic spectra is proposed. It is based on a combination of an experimental approach (multifrequency ESR) and accurate spectra simulation using an improved model, that will be further introduced below. The determined magnetic parameters of the spin probe are directly interpreted in terms of structural information about the spin probe surroundings (lipid bilayer). The obtained magnetic parameters of various spin traps are interpreted by artificial neural networks (ANN) in order to obtain information about the identities of trapped radicals. Then, Density Functional Theory (DFT) calculations are applied to study the mechanism of reactions involving free radicals detected by spin trapping ESR and to calculate magnetic parameters of the radical adducts.

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