Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400466
Title Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging
Author(s) Spoorendonk, K.M.; Hammond, C.L.; Huitema, L.F.A.; Vanoevelen, J.; Schulte-Merker, S.
Source Journal of Applied Ichthyology 26 (2010)2. - ISSN 0175-8659 - p. 219 - 224.
Department(s) Experimental Zoology
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) danio-rerio ostariophysi - osteoblast differentiation - skeletal elements - axial skeleton - retinoic acid - chondrocytes - expression - mutations - osteogenesis - cyprinidae
Abstract For many years bone research has been mainly performed in mice, chicken, cell culture systems or human material from the clinic. In this review, we describe the features of zebrafish (Danio rerio), a relatively new model system in this field. This small teleost offers possibilities which make it a great complement to the mouse: forward genetic screens are possible in fish due to extrauterine development and large brood size, and the recent generation of osteoblast-specific reporter lines allows visualization of osteoblasts in vivo. As key regulators of bone formation are highly conserved between mammals and teleosts, findings in fish likely apply to mammalian osteogenesis and tissue mineralization
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