Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400581
Title Loss of Octarepeats in Two Processed Prion Pseudogenes in the Red Squirrel, Sciurus vulgaris
Author(s) Madsen, O.; Kortum, T.T.; Hupkes, H.; Kohlen, W.; Rheede, T.; Jong, W.W. de
Source Journal of Molecular Evolution 71 (2010)5-6. - ISSN 0022-2844 - p. 356 - 363.
Department(s) Animal Breeding and Genetics
FB SC ICT Infrastructuur
Laboratory of Plant Physiology
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) creutzfeldt-jakob-disease - protein gene prnp - octapeptide repeats - binding - region - copper - prp - susceptibility - polymorphisms - deletion
Abstract The N-terminal region of the mammalian prion protein (PrP) contains an 'octapeptide' repeat which is involved in copper binding. This eight- or nine-residue peptide is repeated four to seven times, depending on the species, and polymorphisms in repeat number do occur. Alleles with three repeats are very rare in humans and goats, and deduced PrP sequences with two repeats have only been reported in two lemur species and in the red squirrel, Sciurus vulgaris. We here describe that the red squirrel two-repeat PrP sequence actually represents a retroposed pseudogene, and that an additional and older processed pseudogene with three repeats also occurs in this species as well as in ground squirrels. We argue that repeat numbers may tend to contract rather than expand in prion retropseudogenes, and that functional prion genes with two repeats may not be viable
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