Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400689
Title Genetic variation of natural antibodies in milk of Dutch Holstein-Friesian cows
Author(s) Ploegaert, T.C.W.; Wijga, S.; Tijhaar, E.; Poel, J.J. van der; Lam, T.J.G.M.; Savelkoul, H.F.J.; Parmentier, H.K.; Arendonk, J.A.M. van
Source Journal of Dairy Science 93 (2010)11. - ISSN 0022-0302 - p. 5467 - 5473.
Department(s) Cell Biology and Immunology
Animal Breeding and Genetics
Adaptation Physiology
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) humoral immune competence - production traits - lactoferrin content - urea nitrogen - laying hens - bovine-milk - parameters - autoantibodies - responses - paratuberculosis
Abstract Defense mechanisms of dairy cows against diseases partly rest on their naturally present disease resistance capacity. Natural antibodies (NAb) form a soluble part of the innate immune system, being defined as antibodies circulating in animals without prior intentional antigenic stimulation. Genetic selection on NAb titers in milk, therefore, might improve disease resistance. We estimated genetic parameters of NAb titers binding lipopolysaccharide, lipoteichoic acid (LTA), peptidoglycan, and keyhole limpet hemocyanin, and titers of the NAb isotypes IgG1, IgM, and IgA binding LTA in milk of Dutch Holstein-Friesian heifers. Natural antibody titers were measured in 1 milk sample from each of 1,939 Holstein-Friesian heifers and used for estimating genetic parameters of NAb titers. The data show that phenotypic variation exists among heifers in NAb titers binding lipopolysaccharide, LTA, peptidoglycan, and keyhole limpet hemocyanin, and the NAb isotypes IgG1, IgM, and IgA binding LTA in milk. High genetic correlations among NAb (ranging from 0.45 to 0.99) indicated a common genetic basis for the levels of different NAb in bovine milk. Intra-herd heritability estimates for NAb ranged from 0.10 to 0.53. The results indicated that NAb levels have potential for genetic selection
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