Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400711
Title Beta-carotene affects gene-expression in lungs of male and female Bcmo1-/-mice in opposite directions
Author(s) Helden, Y.G.J.; Godschalk, R.W.L.; Swarts, J.J.M.; Hollman, P.C.H.; Schooten, F.J. van; Keijer, J.
Source Cellular and Molecular Life Sciences 68 (2011)3. - ISSN 1420-682X - p. 489 - 504.
DOI http://dx.doi.org/10.1007/s00018-010-0461-0
Department(s) RIKILT - Business Unit Safety & Health
Human and Animal Physiology
Rikilt B&T Toxicologie en Effectanalyse
VLAG
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) nitric-oxide synthase - base-line characteristics - retinol efficacy trial - vitamin-a - cardiovascular-disease - epidemiologic evidence - cancer incidence - estrous-cycle - double-tracer - women
Abstract Molecular mechanisms triggered by high dietary beta-carotene (BC) intake in lung are largely unknown. We performed microarray gene expression analysis on lung tissue of BC supplemented beta-carotene 15,150-monooxygenase 1 knockout (Bcmo1-/-) mice, which are—like humans—able to accumulate BC. Our main observation was that the genes were regulated in an opposite direction in male and female Bcmo1-/- mice by BC. The steroid biosynthetic pathway was overrepresented in BC-supplemented male Bcmo1-/- mice. Testosterone levels were higher after BC supplementation only in Bcmo1-/- mice, which had, unlike wild-type (Bcmo1?/?) mice, large variations. We hypothesize that BC possibly affects hormone synthesis or metabolism. Since sex hormones influence lung cancer risk, these data might contribute to an explanation for the previously found increased lung cancer risk after BC supplementation (ATBC and CARET studies). Moreover, effects of BC may depend on the presence of frequent human BCMO1 polymorphisms, since these effects were not found in wild-type mice.
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