Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400797
Title From peptides and proteins to micro-structure mechanics and rheological properties of fibril systems
Author(s) Linden, E. van der
Source Food Hydrocolloids 26 (2012)2. - ISSN 0268-005X - p. 421 - 426.
Department(s) Physics and Physical Chemistry of Foods
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) beta-lactoglobulin fibrils - amyloid fibrils - percolation concentration - colloidal rods - ph 2 - gels - aggregation - hydrolysis - assemblies - elasticity
Abstract This article provides a summary of an example of how relationships between molecular scale properties and macroscopic properties are formulated, in this case with a focus on fibril microstructures and according system elasticity. Entropy plays a dominant role on all length scales. The elasticity is reviewed in terms of the micro-mechanical properties of the fibrils over a wide range of concentrations. The elasticity is concluded to be of an entropic nature. The micro-mechanical fibril property is the persistence length. For fibrils based on globular proteins the response to temperature change and flow has been reported to be either reversible or non-reversible, dependent on the age of the fibril. The reversibility is argued to be related to the fact that the fibril consists of peptides originating from hydrolysis of the globular proteins, and that the initial step of fibrillar peptide assembly is entropic of nature. The longer term irreversibility is speculated to be caused by a secondary assembly step being a collective transition into inter-beta-sheets
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