Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 400875
Title Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey
Author(s) Mbugi, E.V.; Meijerink, M.; Veenemans, J.; Jeurink, P.V.; McCall, M.; Olomi, R.M.; Shao, J.F.; Verhoef, H.; Savelkoul, H.F.J.
Source Malaria Journal 9 (2010). - ISSN 1475-2875 - 13 p.
DOI http://dx.doi.org/10.1186/1475-2875-9-130
Department(s) Cell Biology and Immunology
Host Microbe Interactomics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) zinc supplementation - innate immunity - trace-elements - tnf-alpha - malaria - cells - expression - induction - monocytes - interleukin-12
Abstract Background - Deficiencies in vitamins and mineral elements are important causes of morbidity in developing countries, possibly because they lead to defective immune responses to infection. The aim of the study was to assess the effects of mineral element deficiencies on early innate cytokine responses to Plasmodium falciparum malaria. Methods - Peripheral blood mononuclear cells from 304 Tanzanian children aged 6-72 months were stimulated with P. falciparum-parasitized erythrocytes obtained from in vitro cultures. Results - The results showed a significant increase by 74% in geometric mean of TNF production in malaria-infected individuals with zinc deficiency (11% to 240%; 95% CI). Iron deficiency anaemia was associated with increased TNF production in infected individuals and overall with increased IL-10 production, while magnesium deficiency induced increased production of IL-10 by 46% (13% to 144%) in uninfected donors. All donors showed a response towards IL-1ß production, drawing special attention for its possible protective role in early innate immune responses to malaria. Conclusions - In view of these results, the findings show plasticity in cytokine profiles of mononuclear cells reacting to malaria infection under conditions of different micronutrient deficiencies. These findings lay the foundations for future inclusion of a combination of precisely selected set of micronutrients rather than single nutrients as part of malaria vaccine intervention programmes in endemic countries
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