Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 401013
Title Common carp have two subclasses of bonyfish specific antibody IgZ showing differential expression in response to infection
Author(s) Ryo, S.; Wijdeven, R.H.M.; Tyagi, A.; Hermsen, G.J.; Kono, T.; Karunasagar, I.; Rombout, J.H.W.M.; Sakai, H.; Verburg-van Kemenade, B.M.L.; Savan, R.
Source Developmental and Comparative Immunology 34 (2010)11. - ISSN 0145-305X - p. 1183 - 1190.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) immunoglobulin heavy-chain - phylogenetically primitive vertebrate - paralichthys-olivaceus igd - constant-region genes - cyprinus-carpio - atlantic salmon - japanese flounder - channel catfish - trypanoplasma-borreli - sequence-analysis
Abstract Immunoglobulin heavy chains identified in bony fish are broadly classified into three classes namely IgM, IgD and IgZ. The most recently described isotype is IgZ, a teleosts-fish specific isotype that shows variations in gene structure across teleosts. In this study we have identified two IgZ subclasses in common carp. IgZ1 is a four constant heavy chain domains containing antibody isolated across teleosts and IgZ2 is a two constant domains containing heavy chain chimera with a µ1 and ¿4 domain. Sequence analyses suggest that these subtypes are expressed from two separate genomic loci. Expression analyses show that IgZ1 is more abundant in systemic organs and IgZ2 chimera is preferentially expressed at mucosal sites. The basal expression level of IgM in fish is much higher than of the other isotypes. We show that IgZ1 expression in systemic and mucosal organs is responsive to blood parasites, while mucosal parasite infection induces IgM and IgZ2 gene expression. This report is the first to show differential expression of the IgZ variants in response to pathogens and suggests that the IgZ subtypes in carps may have mutually exclusive humoral functions
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