Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 401063
Title Citrus/Cydonia comp. for seasonal allergic rhinitis: a randomized study to compare treatment effects of the subcutaneous and the nasal reoutes of administration
Author(s) Baars, E.; Jong, M.; Savelkoul, H.F.J.
Source In: Abstracts ECIM Congress, Third European Congress for Integrative Medicine (ECIM), Berlin, Germany, 3-4 December 2010. - - p. 193 - 193.
Event Third European Congress for Integrative Medicine (ECIM), Berlin, Germany, 2010-12-03/2010-12-04
DOI http://dx.doi.org/10.1016/j.eujim.2009.08.093
Department(s) Cell Biology and Immunology
WIAS
Publication type Abstract in scientific journal or proceedings
Publication year 2010
Abstract Objectives - Allergic rhinitis is a condition characterized by sneezing, watery nasal discharge, nasal obstruction and itching. It is an increasingly prevalent condition, particularly in the Western world where it affects around 20% of the adult population. Citrus/Cydonia comp. is an anthroposophic medicine, which contains extracts of lemon (Citrus lemon) and quince (Cydonia oblongata). Several observational studies have shown that Citrus/Cydonia comp. solution either as a subcutaneous injection or as a nasal spray might be an effective treatment for seasonal allergic rhinitis (SAR) patients. In addition, in vitro is has been shown that it has a selective effect on the differentiation of T-cells by producing relatively more IL-10 than IL-12. By that, it also seems to have an effect on the induction of regulatory (IL-10 producing) T-cell subsets. Therefore, it has been concluded that Citrus/Cydonia comp., at least in vitro, is capable of neutralizing (to some extent) the changes, characteristic to allergic rhinitis, with regard to the maturation, differentiation, and activity of the immune system. The aim of the present study is to compare the efficacy and safety of subcutaneous versus nasal spray administration in SAR patients by specifically investigating which route of administration is more effective in the differentiation and inductions of (regulatory) T-cells. Methods - A national, randomized, comparative clinical trial with two parallel groups. A total of 28 patients with grass pollen SAR are recruited at primary care practices or through advertisements. After a 2-week run-in period without allergy medication, patients are randomized to a 6 weeks treatment period with either Citrus/Cydonia comp. 1% subcutaneous injections (2 injections per week) or Citrus/Cydonia comp. 1% nasal spray (1–2 sprays in each nostril, 4 times a day). The primary outcome variables are changes in immunological parameters such as IL-10, IL-12 and IL-5 at week 6, as studied in PBMCs isolated from the blood of the patients. Further objectives are to investigate the influence of Citrus/Cydonia comp. subcutaneous injections versus Citrus/Cydonia comp. nasal spray on the change in clinical symptoms by means of nasal and non-nasal symptom scores. The safety and tolerability of both injections and nasal spray will be investigated by determining adverse events surveillance. Results and conclusions - The outcome of this randomized comparative study will be presented at the congress
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