Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 401102
Title Lactobacillus strains differentially modulate cytokine production by hPBMC from pollen allergic patients
Author(s) Vissers, Y.M.; Snel, J.; Zuurendonk, P.F.; Kleerebezem, M.; Wichers, H.J.; Savelkoul, H.F.J.
Source FEMS Immunology and Medical Microbiology 61 (2011)1. - ISSN 0928-8244 - p. 28 - 40.
Department(s) Cell Biology and Immunology
Microbiological Laboratory
FBR Fresh Supply Chains
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) blood mononuclear-cells - lactic-acid bacteria - regulatory t-cells - tumor-necrosis-factor - in-vitro - probiotic bacteria - intestinal microbiota - food allergy - immunomodulatory properties - mucosal immunology
Abstract The objective of this study was to assess the potential immunomodulatory effect of six Lactobacillus strains on human peripheral blood mononuclear cells (hPBMC) isolated from allergic patients. hPBMC from patients allergic to birch pollen or grass pollen were cultured in vitro in the presence or absence of selective bacterial strains. Cultures were left unstimulated or stimulated with aCD3/aCD28 or Bet v 1. After 1, 4 and 8 days, cells and culture supernatants were harvested and the effect on cellular proliferation and the supernatant levels of several cytokines was assessed. All strains had the ability to repress IL-13 production but did show a differential effect on IFN-¿ induction. Both strains B223 and B1697 showed a lower IFN-¿, IL-12 and TNF-a induction as compared with the other tested strains. Strain B633 showed the best proliferation-suppressive properties in aCD3/aCD28-stimulated cells. Suppression of the T-helper type 2 (Th2) cytokine induction and induction of the Th1 cytokine production by specific strains might be beneficial for allergic patients having a disturbed Th1/Th2 immune balance. Furthermore, hPBMC of patients with seasonal allergy outside the pollen season can be used to determine the immunomodulatory activities of probiotic bacteria
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