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Record number 401121
Title Serum 25-hydroxy-vitamin D3 concentrations increase during tuberculosis treatment in Tanzania
Author(s) Tostmann, A.; Wielders, J.P.M.; Kibiki, G.S.; Verhoef, H.; Boeree, M.J.; Ven, A.J.A.M. van der
Source The International Journal of Tubercolosis and Lung Disease 14 (2010)9. - ISSN 1027-3719 - p. 1147 - 1152.
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) vitamin-d metabolism - pulmonary tuberculosis - immune regulation - human-monocytes - d deficiency - inhibition - rifampicin - interferon - infection - cyp3a4
Abstract SETTING: Vitamin D deficiency is associated with susceptibility to active tuberculosis (TB) in many settings. In vitro studies and studies on human volunteers showed that two of the first-line anti-tuberculosis drugs, isoniazid and rifampicin, reduce 25-hydroxy vitamin D (25[OH]D) concentrations. OBJECTIVE: To study changes in vitamin D status during treatment of Tanzanian hospitalised patients with pulmonary TB (PTB). DESIGN: We compared serum 25[OH]D concentrations in 81 Tanzanian PTB patients before and after 2 months of treatment. RESULTS: Median serum 25[OH]D concentrations increased from 91 nmol/l at baseline to 101 nmol/l after 2 months of TB treatment (median increase 6.0 nmol/l, IQR -0.7-25.0, P = 0.001). Median serum parathyroid hormone concentrations increased from 1.6 to 2.0 pmol/l (median increase 0.46, IQR -0.2-1.1, P <0.001). CONCLUSION: 25[OH]D serum concentrations increased during the first 2 months of TB treatment in 81 PTB patients in northern Tanzania. Improved dietary intake and increased sunlight exposure may have contributed to the increased 25[OH]D concentrations
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