Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 401507
Title Diagnosis of the first cases of scrapie in Poland
Author(s) Polak, M.P.; Larska, M.; Langeveld, J.P.M.; Buschmann, A.; Groschup, M.H.; Zmudzinski, J.F.
Source The Veterinary Journal 186 (2010)1. - ISSN 1090-0233 - p. 47 - 52.
Department(s) CVI Infection Biology
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) bovine spongiform encephalopathy - atypical scrapie - prion protein - monoclonal-antibodies - prp genotypes - sheep - nor98 - discrimination - strains - norway
Abstract This is the first report of cases of scrapie in Poland. The disease was an atypical phenotype, diagnosed in two aged sheep which were found dead. Brainstem samples from both animals were positive on the applied ELISA rapid test, while the confirmatory immunoblot indicated abnormal banding patterns of protease resistant prion protein (PrPres). The genotypes of these sheep were ALRQ/ALHQ and ALRQ/ALRR. The absence of premonitory clinical signs, the advanced age of the affected sheep, the higher concentration of PrPres in the cerebellum relative to the obex, the unusual banding profile of the prion protein and its relatively low resistance to proteolytic degradation confirmed the diagnosis of atypical scrapie (Nor98-like) in both cases
There are no comments yet. You can post the first one!
Post a comment
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.