Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 401884
Title Isoprenoid biosynthesis in Archaea - Biochemical and evolutionary implications
Author(s) Matsumi, R.; Atomi, H.; Driessen, A.J.M.; Oost, J. van der
Source Research in Microbiology 162 (2011)1. - ISSN 0923-2508 - p. 39 - 52.
DOI https://doi.org/10.1016/j.resmic.2010.10.003
Department(s) Microbiological Laboratory
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) geranylgeranyl-diphosphate synthase - enantiomeric glycerophosphate backbone - aerobic hyperthermophilic archaeon - isopentenyl phosphate kinase - chain-length determination - bipolar tetraether lipids - non-mevalonate pathway - aeropyrum-pernix k1 - ether polar
Abstract Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction. In Archaea, isoprenoid compounds constitute the hydrophobic moiety of the typical ether-linked membrane lipids. With respect to stereochemistry and composition, these archaeal lipids are very different from the ester-linked, fatty acid-based phospholipids in bacterial and eukaryotic membranes. This review provides an update on isoprenoid biosynthesis pathways, with a focus on the archaeal enzymes. The black-and-white distribution of fundamentally distinct membrane lipids in Archaea on the one hand, and Bacteria and Eucarya on the other, has previously been used as a basis for hypothetical evolutionary scenarios, a selection of which will be discussed here
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