Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 402387
Title the role of mathematical modelling in understanding the epidemiology and control of sheep transmissible spongiform encephalopathies: a review
Author(s) Gubbins, S.; Touzeau, S.; Hagenaars, T.H.J.
Source Veterinary Research 41 (2010)4. - ISSN 0928-4249 - p. 41:42 - 41:42.
Department(s) CVI Diagnostics and Crisis
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) prion protein genotype - great-britain - classical scrapie - natural scrapie - british sheep - population-dynamics - norwegian sheep - bse infection - suffolk sheep - prp genotype
Abstract To deal with the incompleteness of observations and disentangle the complexities of transmission much use has been made of mathematical modelling when investigating the epidemiology of sheep transmissible spongiform encephalopathies (TSE) and, in particular, scrapie. Importantly, these modelling approaches allow the incidence of clinical disease to be related to the underlying prevalence of infection, thereby overcoming one of the major difficulties when studying these diseases. Models have been used to investigate the epidemiology of scrapie within individual flocks and at a regional level; to assess the efficacy of different control strategies, especially selective breeding programmes based on prion protein (PrP) genotype; to interpret the results of scrapie surveillance; and to inform the design of surveillance programmes. Furthermore, mathematical modelling has played an important role when assessing the risk to human health posed by the possible presence of bovine spongiform encephalopathy in sheep. Here, we review the various approaches that have been taken when developing and analysing mathematical models for the epidemiology and control of sheep TSE and assess their impact on our understanding of these diseases. We also identify areas that require further work, discuss future challenges and identify data gaps.
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