Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 402590
Title Quantitative genotyping to estimate genetic contributions to pooled samples and genetic merit of the contributing entities
Author(s) Kinghorn, B.P.; Bastiaansen, J.W.M.; Ciobanu, M.; Steen, H.A.M. van der
Source Acta Agriculturae Scandinavica Section A-Animal Science 60 (2010)1. - ISSN 0906-4702 - p. 3 - 12.
Department(s) Animal Breeding and Genetics
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) admixture
Abstract Genotyping required to track family membership in aquaculture breeding programs is reduced dramatically by estimating the contributions of different families to pooled samples of tissue. This approach is relevant to widely differing scenarios involving animals, plants, and microbes. For the family membership scenario, SNP markers are genotyped for the contributing families' parents, and quantitatively genotyped to estimate allele frequencies within the mixed-family pooled tissue. Results are used to infer proportional contributions of the different families to the pool. Different computational strategies were tested for bias and sampling error. A correlation of 99% between estimated and true genetic contributions was achieved using 20 (50) randomly chosen SNPs at a standard error of allele frequency estimates of 0.01 (0.02). Optimal grouping of families and choice of markers further increases performance markedly. Trait means and distributions of families can be quite accurately estimated by tissue sampling across the range of trait values
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