Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 403030
Title Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks
Author(s) Nodelijk, G.; Roermund, H.J.W. van; Keulen, L.J.M. van; Engel, B.; Vellema, P.; Hagenaars, T.H.J.
Source Veterinary Research 42 (2011)1. - ISSN 0928-4249 - p. 5 - 5.
DOI http://dx.doi.org/10.1186/1297-9716-42-5
Department(s) CVI Diagnostics and Crisis
ASG Infectieziekten
CVI Infection Biology
Biometris (WU MAT)
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) natural scrapie - prion protein - prp genotype - british sheep - immunohistochemical detection - clinical signs - transmission - bse - dynamics - gene
Abstract Susceptibility to scrapie, a transmissible spongiform encephalopathy in sheep, is modulated by the genetic make-up of the sheep. Scrapie control policies, based on selecting animals of resistant genotype for breeding, have recently been adopted by the Netherlands and other European countries. Here we assess the effectiveness of a breeding programme based on selecting rams of resistant genotype to obtain outbreak control in classical scrapie-affected sheep flocks under field conditions. In six commercially-run flocks following this breeding strategy, we used genotyping to monitor the genotype distribution, and tonsil biopsies and post-mortem analyses to monitor the occurrence of scrapie infection. The farmers were not informed about the monitoring results until the end of the study period of six years. We used a mathematical model of scrapie transmission to analyze the monitoring data and found that where the breeding scheme was consistently applied, outbreak control was obtained after at most four years. Our results also show that classical scrapie control can be obtained before the frequency of non-resistant animals is reduced to zero in the flock. This suggests that control at the national scale can be obtained without a loss of genetic polymorphisms from any of the sheep breeds
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