Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 403151
Title Fully automated screening of veterinary drugs in milk by turbulent flow chromatography and tandem mass spectrometry
Author(s) Stolker, A.A.M.; Peters, R.J.B.; Zuiderent, R.; DiBussolo, J.M.; Martins, C.P.B.
Source Analytical and Bioanalytical Chemistry 397 (2010)7. - ISSN 1618-2642 - p. 2841 - 2849.
Department(s) RIKILT - R&C Diergeneesmiddelen
RIKILT - R&C Contaminanten
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) strategies - extraction
Abstract There is an increasing interest in screening methods for quick and sensitive analysis of various classes of veterinary drugs with limited sample pre-treatment. Turbulent flow chromatography in combination with tandem mass spectrometry has been applied for the first time as an efficient screening method in routine analysis of milk samples. Eight veterinary drugs, belonging to seven different classes were selected for this study. After developing and optimising the method, parameters such as linearity, repeatability, matrix effects and carry-over were studied. The screening method was then tested in the routine analysis of 12 raw milk samples. Even without internal standards, the linearity of the method was found to be good in the concentration range of 50 to 500 µg/L. Regarding repeatability, RSDs below 12% were obtained for all analytes, with only a few exceptions. The limits of detection were between 0.1 and 5.2 µg/L, far below the maximum residue levels for milk set by the EU regulations. While matrix effects—ion suppression or enhancement—are obtained for all the analytes the method has proved to be useful for screening purposes because of its sensitivity, linearity and repeatability. Furthermore, when performing the routine analysis of the raw milk samples, no false positive or negative results were obtained
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