Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 403901
Title Mobility of fluorescently labeled polymer micelles in living cells
Author(s) Li, F.; Westphal, A.H.; Marcelis, A.T.M.; Sudhölter, E.J.R.; Cohen Stuart, M.A.; Leermakers, F.A.M.
Source Soft Matter 7 (2011). - ISSN 1744-683X - p. 1214 - 1218.
DOI https://doi.org/10.1039/c0sm00835d
Department(s) Laboratory for Organic Chemistry
Biochemistry
Physical Chemistry and Colloid Science
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) drug-delivery systems - correlation spectroscopy - nanocontainers - complexes - receptor - binding - cancer - shell
Abstract Stabilized fluorescent polymeric micelles were made that are spontaneously taken up into the cytoplasm of human cells. The mobility of these micelles in living cells was probed on a molecular level for the first time with FCS. Importantly, the present micelles do not interact with proteins, membranes or cellular organelles. This system provides a new nanotechnological tool which is biocompatible, versatile and easy to use, especially since after further chemical modification, they could be targeted to specific subcellular locations.
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