Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 403919
Title SUMO-, MAPK- and resistance protein-signaling converge at transcription complexes that regulate plant innate immunity
Author(s) Burg, H.A. van den; Takken, F.L.W.
Source Plant Signaling & Behavior 5 (2010)12. - ISSN 1559-2316 - p. 1587 - 1591.
Department(s) Laboratory of Phytopathology
Publication type Refereed Article in a scientific journal
Publication year 2010
Abstract Upon pathogen perception plant innate immune receptors activate various signaling pathways that trigger host defenses. PAMP-triggered defense signaling requires mitogen-activated protein kinase (MAPK) pathways, which modulate the activity of transcription factors through phosphorylation. Here, we highlight that the same transcription factors are also targets for conjugation by SUMO (Small ubiquitin-like modifier). SUMO conjugation determines recruitment and activity of chromatin-modifying enzymes, and thereby indirectly controls gene expression. SUMO conjugation is essential to suppress defense signaling in non-infected plants. Resistance protein signaling and SUMO conjugation also converge at transcription complexes. For example, the TIR-NB-LRR protein SNC1 interacts with histone deacetylase HDA19 and the transcriptional co-repressor Topless-related 1; both are SUMO targets. We present a model in which SUMO conjugation can transform transcription activators into repressors, thereby preventing defense induction in the absence of a pathogen.
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