Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 404149
Title Comment on: Low prevalence of resistance to azols in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies
Author(s) Verweij, P.E.; Camps, S.M.T.; Kema, G.H.J.; Melchers, W.J.G.
Source Journal of Antimicrobial Chemotherapy 66 (2011)4. - ISSN 0305-7453 - p. 954 - 955.
Department(s) PRI BIOINT Moleculair Phytopathology
Publication type Refereed Article in a scientific journal
Publication year 2011
Abstract Azole resistance is an emerging clinical problem in patients with Aspergillus infections, primarily those caused by Aspergillus fumigatus. Alanio et al. 1 describe the results of a study that investigated the prevalence of azole resistance in 118 clinical Aspergillus isolates obtained from a cohort of 89 patients with haematological malignancy. They found only one azole-resistant A. fumigatus isolate, which corresponded to a prevalence of 0.85%. 1 Although the low prevalence of resistance may be reassuring, the circumstances surrounding the resistant isolate are a cause of great concern. The azole-resistant isolate was cultured from an azole-naive patient, which precludes resistance development through azole therapy. The only other possibility is that the patient acquired the resistant isolate from the environment, as A. fumigatus is …
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