Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 405237
Title Triggered Templated Assembly of Protein Polymersomes
Author(s) Li, F.; Wolf, F.A. de; Marcelis, A.T.M.; Sudhölter, E.J.R.; Stuart, M.A.C.; Leermakers, F.A.M.
Source Angewandte Chemie-International Edition 49 (2010)51. - ISSN 1433-7851 - p. 9947 - 9950.
DOI http://dx.doi.org/10.1002/anie.201004003
Department(s) Laboratory for Organic Chemistry
FBR Bioconversion
Physical Chemistry and Colloid Science
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) aqueous-solution - vesicles - copolymers
Abstract Trigger the block: Stable biocompatible protein polymersomes can be generated by a triggered templated self-assembly route (see picture). Pluronic L121 vesicles (red core with blue corona) take up a biosynthetic triblock copolymer CSXSXC into their unilamellar shell. In response to changes in pH (trigger), the S block becomes hydrophobic and adapts to the template vesicle, thus directing the formation of protein polymersomes.
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