Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 405672
Title Fungal LysM effectors perturb chitin-triggered host immunity
Author(s) Jonge, R. de; Kombrink, A.; Esse, P. van; Shibuya, N.; Thomma, B.P.H.J.
Source In: Book of Abstracts 26th Fungal Genetics Conference, Asilomar, Pacific Grove, California, USA, 15-20 March 2011. - - p. 49 - 49.
Event 26th Fungal Genetics Conference, Asilomar, Pacific Grove, California, USA, 2011-03-15/2011-03-20
Department(s) Laboratory of Phytopathology
EPS-2
Publication type Abstract in scientific journal or proceedings
Publication year 2011
Abstract Cladosporium fulvum is a biotrophic fungal pathogen that causes leaf mould of tomato. The in planta abundantly secreted C. fulvum effector Ecp6 (for extracellular protein 6) acts as a potent virulence factor. The Ecp6 protein contains three lysin motifs (LysMs), protein domains that were also identified in plant cell surface receptors that activate host immunity upon perception of chitin oligosaccharide PAMPs, breakdown products of fungal cell walls that are released during plant invasion. Affinity precipitation assays showed that Ecp6 is a chitin-binding protein and three binding sites per molecule were detected. We found that Ecp6 does not protect fungal cell walls against hydrolysis by plant chitinases. Rather, Ecp6 appears to prevent the activation of chitin-triggered immunity through scavenging of chitin oligosaccharide PAMPs. Interestingly, homologues of Ecp6 were identified in many fungal species. These effectors are collectively referred to as LysM effectors. A number of LysM effectors from other fungal plant pathogens have been produced. Similar to Ecp6, most of these bind chitin and are able to suppress chitin-triggered immunity. However, in contrast to Ecp6, some LysM effectors protect fungal cell walls against chitinases, while others appear to have different substrates than chitin
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