Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 405813
Title Psychobiological effects of perinatal exposure to odorants in mice. Part II: Behavioural alterations
Author(s) Oostindjer, M.; Ain, S. Al; Patris, B.; Cadiou, H.; Grosmaitre, X.; Schaal, B.
Source In: Abstracts from the XXth Congress of European Chemoreception Research Organization, ECRO-2010, Avignon, France, 14-19 September 2010. - Oxford University Press - p. E76 - E77.
Event XXth Congress of European Chemoreception Research Organization, ECRO-2010, Avignon, France, 2010-09-14/2010-09-19
Department(s) Adaptation Physiology
WIAS
Publication type Abstract in scientific journal or proceedings
Publication year 2011
Abstract Early exposure to odorants pre-, post- or transnatally is known to result in a decreased avoidance or increased preference for these odorants in mammals. There are also indications that olfactory sensitivity for these odorants can be affected. We exposed C57-Bl/6 mice of Mor23-GFP and M71-GFP lines to lyral (LY) or acetophenone (AC), respectively, either transnatally through the water of the mother (1*10-5 M) or postnatally in air for 1 hr per day (20 ll pure). Animals were weaned on postnatal day 20 (P20), and 3 tests were performed: 1) A 3-min exploration test on P20 in a rectangular arena presenting LY and AC under a wire mesh to measure the time spent in each half of the arena. 2) A 2-bottle choice test on P21, whereby LY and AC-flavoured water (1*10-5 M) was provided to assess intake. 3) An olfactory sensitivity test based on an habituation procedure on P21 using two 2-min habituation trials with water and 6 dishabituation trials whereby either LY (in concentrations ranging from 9.77*10-9 to 1.0*10-5 M) or AC (9.54*10-7 to 1.0*10-5 M) was presented to assess time spent exploring and number of visits to the stimuli, assuming increased exploration when the odorant is perceived. Control animals of both lines displayed a preference for LY compared to AC in the exploration test (LY: 99 vs. AC: 81 s, Mor23: p=0.04, M71: p=0.03), while transnatal AC exposure resulted in an absence of preference for either odorant (91 vs. 89 s) and postnatal exposure in a higher preference for AC (78 vs. 108 s, p=0.02). In contrast, LY exposure decreased preference for LY, both trans- and postnatally exposed animals showing no preference for either odour (transnatal: 89 vs. 91; postnatal: 86 vs. 94 s). We furthermore show results of 2-bottle choice test, and the effects of LY and AC exposure on behavioural olfactory sensitivity. These results are linked with density of Mor23- and M71-receptorexpressing olfactory sensory neurons which show high affinity to LY and AC, respectively, presented in the poster by Tazir et al (Part I). This research was supported by a doctoral grant from CNRSRegion Burgundy, and by continued support from Region Burgundy.
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