Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 405891
Title Locus-dependent selection in crop-wild hybrids of lettuce under field conditions and its implication for GM crop development
Author(s) Hooftman, D.A.P.; Flavell, A.J.; Jansen, J.; Nijs, J.C.M. den; Syed, N.H.; Sorensen, A.P.; Wengel, P.O. ter; Wiel, C.C.M. van de
Source Evolutionary Applications 4 (2011)5. - ISSN 1752-4563 - p. 648 - 659.
Department(s) Biometris (PPO/PRI)
WUR Plant Breeding
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) sunflower helianthus-annuus - genetically-modified crops - linkage disequilibrium - gene flow - cultivated sunflower - artificial selection - disease resistance - lactuca-serriola - risk-assessment - transgene flow
Abstract Gene escape from crops has gained much attention in the last two decades, as transgenes introgressing into wild populations could affect the latter’s ecological characteristics. However, different genes have different likelihoods of introgression. The mixture of selective forces provided by natural conditions creates an adaptive mosaic of alleles from both parental species. We investigated segregation patterns after hybridization between lettuce (Lactuca sativa) and its wild relative, L. serriola. Three generations of hybrids (S1, BC1, and BC1S1) were grown in habitats mimicking the wild parent’s habitat. As control, we harvested S1 seedlings grown under controlled conditions, providing very limited possibility for selection. We used 89 AFLP loci, as well as more recently developed dominant markers, 115 retrotransposon markers (SSAP), and 28 NBS loci linked to resistance genes. For many loci, allele frequencies were biased in plants exposed to natural field conditions, including over-representation of crop alleles for various loci. Furthermore, Linkage disequilibrium was locally changed, allegedly by selection caused by the natural field conditions, providing ample opportunity for genetic hitchhiking. Our study indicates that when developing genetically modified crops, a judicious selection of insertion sites, based on knowledge of selective (dis)advantages of the surrounding crop genome under field conditions, could diminish transgene persistence.
There are no comments yet. You can post the first one!
Post a comment
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.