Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 406127
Title A Micronutrient Powder with Low Doses of Highly Absorbable Iron and Zinc Reduces Iron and Zinc Deficiency and Improves Weight-For-Age Z-Scores in South African Children
Author(s) Troesch, B.; Stuijvenberg, M.E. van; Smuts, C.M.; Salome Kruger, H.; Biebinger, R.; Hurrell, R.F.; Baumgartner, J.; Zimmermann, M.B.
Source The Journal of Nutrition 141 (2011)2. - ISSN 0022-3166 - p. 237 - 242.
DOI http://dx.doi.org/10.3945/jn.110.129247
Department(s) Chair Nutrition and Health over the Lifecourse
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) routine prophylactic supplementation - randomized controlled-trials - placebo-controlled trial - fortified fish sauce - ascorbic-acid - complementary foods - phytic acid - ferrous fumarate - home fortification - nutritional-status
Abstract Micronutrient powders (MNP) are often added to complementary foods high in inhibitors of iron and zinc absorption. Most MNP therefore include high amounts of iron and zinc, but it is no longer recommended in malarial areas to use untargeted MNP that contain the Reference Nutrient Intake for iron in a single serving. The aim was to test the efficacy of a low-iron and -zinc (each 2.5 mg) MNP containing iron as NaFeEDTA, ascorbic acid (AA), and an exogenous phytase active at gut pH. In a double-blind controlled trial, South African school children with low iron status (n = 200) were randomized to receive either the MNP or the unfortified carrier added just before consumption to a high-phytate maize porridge 5 d/wk for 23 wk; primary outcomes were iron and zinc status and a secondary outcome was somatic growth. Compared with the control, the MNP increased serum ferritin (P <0.05), body iron stores (P <0.01) and weight-for-age Z-scores (P <0.05) and decreased transferrin receptor (P <0.05). The prevalence of iron deficiency fell by 30.6% (P <0.01) and the prevalence of zinc deficiency decreased by 11.8% (P <0.05). Absorption of iron from the MNP was estimated to be 7–8%. Inclusion of an exogenous phytase combined with NaFeEDTA and AA may allow a substantial reduction in the iron dose from existing MNP while still delivering adequate iron and zinc. In addition, the MNP is likely to enhance absorption of the high native iron content of complementary foods based on cereals and/or legumes.
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