Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 406137
Title A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions
Author(s) Boer, H.M.T.; Stötzel, C.; Röblitz, S.; Deuflhard, P.; Veerkamp, R.F.; Woelders, H.
Source Journal of Theoretical Biology 278 (2011)1. - ISSN 0022-5193 - p. 20 - 31.
Department(s) Adaptation Physiology
LR - Backoffice
Livestock Research
Publication type Refereed Article in a scientific journal
Publication year 2011
Keyword(s) plasma progesterone levels - chemical-reaction systems - suckled beef-cows - dairy-cows - stimulating-hormone - peripheral plasma - menstrual-cycle - dominant follicles - luteolytic signal - ovarian-follicles
Abstract Bovine fertility is the subject of extensive research in animal sciences, especially because fertility of dairy cows has declined during the last decades. The regulation of estrus is controlled by the complex interplay of various organs and hormones. Mathematical modeling of the bovine estrous cycle could help in understanding the dynamics of this complex biological system. In this paper we present a mechanistic mathematical model of the bovine estrous cycle that includes the processes of follicle and corpus luteum development and the key hormones that interact to control these processes. The model generates successive estrous cycles of 21 days, with three waves of follicle growth per cycle. The model contains 12 differential equations and 54 parameters. Focus in this paper is on development of the model, but also some simulation results are presented, showing that a set of equations and parameters is obtained that describes the system consistent with empirical knowledge. Even though the majority of the mechanisms that are included in the model are based on relations that in the literature have only been described qualitatively (i.e. stimulation and inhibition), the output of the model is surprisingly well in line with empirical data. This model of the bovine estrous cycle could be used as a basis for more elaborate models with the ability to study effects of external manipulations and genetic differences.
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